CDC6 and neoplasm: Although the CDC6 mRNA increased with increasing grades of the clinicopathological classifications (except for the T-stage) of SCC, the Kruskal-Wallis test did not reveal statistically significant overall correlation of CDC6 mRNA level with tumor size (P = 0.159), lymph node status (p = 0.145), clinical stage (p = 0.242) or histological grade (p = 0.052).