In addition, the MCM2 expression level increased with increasing grade of dysplasia, with a highly significant difference between the mild and moderate epithelial dysplasia (p < 0.001), between the mild and severe epithelial dysplasia (p = 0.000), and between the moderate and severe epithelial dysplasia (p < 0.001). Here, MCM2 is linked to intraepithelial neoplasia.