To assess this possibility, we genotyped four variants that mapped to the folliculin transcript – the two nonsynonymous variants (rs3744124 and rs41419545) and two common 5' UTR variants (rs1708629 and rs1736209) – in 345 NETT subjects and 420 NAS controls and tested for evidence of genetic association with the presence or absence of COPD. The gene discussed is FLCN; the disease is chronic obstructive pulmonary disease.