There was a significant difference in FEV1 among the individuals with asthma who were CagA+ (N = 76, median % predicted = 82.0 (interquartile range, IQR = 71–92) compared to those who were H. pylori negative (N = 170, median % predicted = 90.0, IQR = 77–100) (p = 0.008), although FEV1/FVC was not different between the two groups (median = 80.0% predicted, IQR = 74.0–86.5 in CagA+ subjects and 82.0%, IQR = 76–85 in H. pylori− subjects) (p = 0.4). The gene discussed is S100A8; the disease is asthma.