The asynchronous pattern of replication of the SNRPN-imprinted locus, consisting of early replication of the paternal allele (exemplified here in cells of the healthy son (K2) of a non-cancer patient) is in accord with the large amount of data documenting an allele-specific parent-of-origin replication mode for this locus in normal human cells [20-24]. Here, SNRPN is linked to cancer.