IFIT1 and systemic lupus erythematosus: IFIT-1 (ISG56, P56) and IFIT-2 (ISG54, P54) are induced in response to type I and type II interferons, dsRNA, LPS, viral [14] and bacterial infections [15] and they are also found in several chronic diseases such as inflammatory bowel disease (IBD) [16] or SLE.