In this perspective, we think that our approach has given a good contribution: in fact we were able to identify some proteins and transcription factors, such as SMAD3/4, GNB2L1/RACK1, MYC, MAX and JUN whose functions have been studied extensively in tumours [73-75] and in some atrophy models [59,60,76]. Here, RACK1 is linked to Atrophy.