This result is supported by recent work from Komatsu et al. (2007) that reported elevated expression of several kallikrein family members in the stratum corneum from AE patients [32], and furthermore by work from Vasilopoulos that identified genetic association between the corneum chymotryptic enzyme (SCCE/KLK7) and AE [33]. The gene discussed is KLK4; the disease is acrodermatitis enteropathica.