HSPD1 and juvenile idiopathic arthritis: Indeed, T-cell reactivity to HSP60 is associated with a good prognosis in juvenile arthritis [8], [54], and the administration of a peptide of HSP60 to newly diagnosed patients with T1DM can arrest the autoimmune destruction of β-cells and induce a Th1 to Th2 shift in the diabetogenic T cells [13].