HSPD1 and type 1 diabetes mellitus: In T1DM, for example, vaccination with HSP60 epitopes activates HSP60-specific regulatory T cells that affect the T-cell response to disease-associated antigens (insulin, glutamic acid decarboxylase and HSP60 itself) by inducing a shift from the secretion of INFγ to IL-10 [3], [18]; HSP60 vaccination induces a similar cytokine shift in the response to the mycobacterial antigens that trigger AA [6], [7].