When mRNA expression was compared in paired samples of primary and metastatic tumor tissue, gene expression was significantly higher in metastatic tumor tissue for each molecular marker: TS, 1.9-fold; DPD, 3.8-fold; TP, 1.6-fold; ERCC1, 2.1-fold (Figure 1). The gene discussed is ERCC1; the disease is metastatic neoplasm.