In this context, the present observations should be considered cautiously in relation to the pathology of hypertension and cardiovascular disease; (5) the functional role of Arg347Cys polymorphism is still unknown, but epidemiological studies have been suggesting that this molecular variant may be associated with blood pressure controlling mechanisms and hypertension status; (6) we have only genotyped the Arg347Cys SNP in the ADRA1A (the most common non-synonymous naturally occurring SNP in the α1A-AR) and other(s) SNP(s) may, in fact, be more relevant for the reported association[19]. This evidence concerns the gene ADRA1A and hypertensive disorder.