It is of general interest to study the most characterised variants in VDR in southern European countries, where sun exposure is typically higher than in northern European countries (maximum UV Index during the summer months = 9 in Spain versus 6.5 in Netherlands) [14,15] In this study, we investigated for the first time the role of polymorphisms in VDR in two epithelial cancers, sporadic BC and MM, in the Spanish population. This evidence concerns the gene VDR and Miyoshi myopathy.