MKI67 and neoplasm: Furthermore, in a multivariate analysis, not only tumor size of 2 cm or more (HR = 4.49, p = 0.0047) and nodal positivity (HR = 4.1, p < 0.0001) but also positive CENP-F (HR = 2.94, p = 0.0015) and Ki67 (HR = 2.05, p = 0.011) showed an independent impact on the DFS of patients (Table 4).