This is the case in a mouse model of pulmonary inflammation (Gerard et al., 2005) and also in rat astrocytes (Gavrilyuk et al., 2005) but several groups have recently reported a pro-inflammatory role for mouse C5L2, albeit without evidence of the involvement of G proteins (Chen et al., 2007; Rittirsch et al., 2008). The gene discussed is C5AR2; the disease is inflammatory response.