Taken together, there appears to be a conflicting function of LMO4 in carcinogenesis as a tumor suppressor or as an oncogene; it is reasonable that LMO4, a transcription regulator, may have multiple functions in individual cancers, like E2F1, an another transcription factor, that was reported both as an oncogene by stimulating cell proliferation [38] and as a tumor suppressor by signaling p53-dependent apoptosis [39]. Here, E2F1 is linked to cancer.