Three genes have been identified for POAG from the reported loci, myocilin (MYOC, OMIM 601652) [17,18], optineurin (OPTN, OMIM 602432) [6,19], and WD repeat-domain 36 (WDR36, OMIM 609669) [12,20]. The gene discussed is OPTN; the disease is open-angle glaucoma.