We found that incubation of NORE1A protein for 30 minutes at 37°C with extracts of human lung cancer cell lines H358 (bronchoalveolar carcinoma) and H460 (large cell carcinoma) resulted in proteolysis of the NORE1A protein (Figure 1, lanes 2 and 3). The gene discussed is RASSF5; the disease is large cell carcinoma.