As shown on Figure 4C, extracts from tumors taken from patients 3, 9 and 10 were capable of inducing NORE1A cleavage and degradation (lanes 4, 6 and 8) while extract from tumor taken from patient 8 (lane 10), as well as extracts taken from six other patients (data not shown) did not induce NORE1A cleavage. The gene discussed is RASSF5; the disease is neoplasm.