PTEN and breast cancer: In2005, two independent laboratories confirmed Patel’s suspicion that PPARγ induces PTEN transcription in a breast cancer setting[21, 22].We demonstrated that of the four TZDs, only Rosi had the ability to induce PTEN transcription and subsequently itsprotein expression in MCF-7 cells [21].Furthermore, we showed that stimulation with Rosi induces a PTEN protein thatis both protein- and lipid-phosphatase active, as evidenced by decreasedphosphorylation of Aktand MAPK concomitant with PTEN expression.Additionally, Rosi treatment induced G1 arrest that paralleled with PTENexpression.