In2005, two independent laboratories confirmed Patel’s suspicion that PPARγ induces PTEN transcription in a breast cancer setting[21, 22].We demonstrated that of the four TZDs, only Rosi had the ability to induce PTEN transcription and subsequently itsprotein expression in MCF-7 cells [21].Furthermore, we showed that stimulation with Rosi induces a PTEN protein thatis both protein- and lipid-phosphatase active, as evidenced by decreasedphosphorylation of Aktand MAPK concomitant with PTEN expression.Additionally, Rosi treatment induced G1 arrest that paralleled with PTENexpression. This evidence concerns the gene PTEN and breast carcinoma.