In contrast to these studies,Ikezoe et al. did not observe any PPARγ alterations in their colon cancer study;however they limited their study to only exons 3 and 5 of PPARγ[32].These studies indicate that PPARγ is indeed a tumor suppressor in the coloncancer setting; however none of these studies tested if the TZDs could effectthe cancer’s progression. The gene discussed is PPARG; the disease is malignant colon neoplasm.