PTEN and neuroblastoma: Lee et al. observed an inhibition of cellular proliferationand Akt phosphorylationin accord with an increase in G1 arrest and PTEN protein expression in A549lung cancer cells [24].Subsequently, PPARγ has been shown to upregulate PTEN expressionin nonsmall cell lung cancer, neuroblastoma, adrenocortical, pancreatic,heptocarcinoma, and thyroid cell lines[23, 25, 26].