Thus, CB1-mediated inhibitory effects on these two neurotransmittersystems could be one of the explanations for the observed bell-shapeddose-response curve induced by AEA in this region as well as the contradictoryresults regarding the effects of cannabinoids on anxiety (see Table 1 and text bellow for a discussion on the possible involvement of TRPV1 receptors). This evidence concerns the gene CNR1 and Anxiety.