PDGFRL and invasive carcinoma: The second position of the combined ranking that takes into account the WGAS results is occupied by the platelet-derived growth factor receptor-like (PDGFRL) gene, while the first gene in the combined rank is PDGFRA (Figure 7). PDGFRA is expressed in invasive carcinomas and is associated with aggressiveness [74], and, importantly, PDGFRL is mutated in cancer cells [75,76] and maps at chromosome 8p22-p21, where it is thought to map a breast cancer tumor suppressor gene(s) [77-79].