Since all the main polyphenols that occur at high levels in EVOO have demonstrated antioxidant activity and antioxidants are believed to be responsible for a number of EVOO's biological activities, we envisioned that EVOO polyphenols-induced depletion of HER2 might represent a general response of HER2-overexpressing cancer cells growing upon anti-oxidant conditions. The gene discussed is ERBB2; the disease is cancer.