Since the ability of EVOO polyphenols to deplete HER2 protein did not appear to relate to their impact on the antioxidant status of breast cancer cells, we then speculated that EVOO secoiridoids and lignans might deplete HER2 through proteolysis, the molecular mechanism through which other structurally related plant polyphenols such as the flavonoids apigenin and luteolin suppress HER2 protein expression in breast cancer cells [41-43]. This evidence concerns the gene ERBB2 and breast carcinoma.