Although one observational study is not sufficient and consistency of findings across multiple cohort and case-control studies is paramount to definitely establish whether the protective effect of a diet rich in raw vegetables and OO is largely restricted to HER2-positive breast carcinomas, when considering experimental and epidemiological evidence together it is reasonable to suggest that dietary factors influencing the occurrence of HER2-positive breast carcinomas may differ from those influencing the occurrence of HER2-negative cancers [6]. This evidence concerns the gene ERBB2 and breast carcinoma.