In contrast to the results obtained by Wang et al., LacZ-(CUG)400 RNAs aggregate exclusively in the cytoplasm and do not result in aberrant splice site selection in several RNAs implicated in DM1 including Tnnt2, Alp, Zasp and m-Titin [Figure 6]. This evidence concerns the gene PDLIM3 and myotonic dystrophy type 1.