DMPK and myotonic dystrophy type 1: Consistent with these earlier results, inducible expression of high levels of interrupted CUG repeat tracts expressed in the context of the DMPK 3′UTR, under the control of a strong ubiquitous promoter, has also been shown to result in the rapid aggregation of CUG repeats within the nucleus and the development of severe DM1 pathology in mice [24], [39].