In the univariate analysis, the variables that were associated with early mortality were haematological (p = 0.004) and liver failure (p = 0.005) according to the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) definition [16]; inappropriate initial antibiotic treatment (p = 0.03); acquisition site of the infection (p = 0.007), with early mortality higher in patients with community-acquired infections than in those that acquired the infection after admission to the ICU (25.6% vs 0%, p < 0.001), and LODS score (p = 0.02). The gene discussed is PROC; the disease is Hepatic failure.