APOE and Alzheimer disease: The critical dependence of Aβ deposition in plaques on the presence of apoE has also been confirmed in AD Tg amyloid precursor protein (APP)V717F/apoE-/- mice, which have a delayed onset of Aβ deposition, a reduced Aβ load, and no fibrillar Aβ deposits compared with APPV717F/apoE+/+ Tg mice.