Compared to cells from AD patients, control cells up-regulated (>2.2-fold) the transcription of 35 genes and expressed sequence tags (ESTs), including MGAT3 (327-fold, P < 0.001), and the genes encoding fibronectin (FN1; 10.1-fold, P < 0.001), cholinergic receptor, muscarinic 4 (9.3-fold, P < 0.001), and 2'-5'-oligoadenylate synthetase 3 (OAS; 7.8-fold, P < 0.001), and down-regulated (>2-fold) the transcription of an additional 35 genes or ESTs. This evidence concerns the gene MGAT3 and Alzheimer disease.