In addition, Runx1 is a target of one of the most common translocations t(8;21) in acute myeloid leukemia (AML), which generates the dominant-negative Runx1-ETO fusion protein to suppress Runx1 activity, leading to the blockade of myeloid lineage differentiation and an accumulated progenitor pool that is prone to malignant transformation [60]. Here, RUNX1T1 is linked to acute myeloid leukemia.