One-way ANOVA showed that the mean p53 value in OSCC (38.4±34.9) was significantly higher (F=8.8; p<.01) than those found in controls and in oral lesions either with or without dysplasia (respectively, 8.3± 3.5, 21.3±27.1, and 10.8 ±6.9). This evidence concerns the gene TP53 and dysplasia.