Furthermore, if we consider samples with low p53 expression as lesions “not at risk” of developing cancer, the occurrence of p53-negative lesions in our population of severe epithelial dysplasias is too high, considering that most of them were situated at margins of OSCC and thus at very high risk of malignant changes [38-39]. The gene discussed is TP53; the disease is intraepithelial neoplasia.