In the present study, high Ki67/p53 ratios were found in 83% of OSCC with low p53 expression and even in 71% of severe epithelial dysplasias with low p53 values, and the combination of samples with p53 over-expression and samples with low p53 values but high Ki67/p53 ratio, led to a very high association with OSCC and epithelial dysplasias. Here, TP53 is linked to intraepithelial neoplasia.