SNPs rs10830962, rs4753426, and rs10830963 revealed marked associations with higher fasting plasma glucose concentrations (all p<0.0001 after adjustment for gender, age, BMI, and family history of diabetes), with lower values in all OGTT-derived measures of insulin release (all p≤0.0007 after adjustment for gender, age, BMI, insulin sensitivity, and family history of diabetes; Tables 3 and 4), and with lower values of the disposition index (all p<0.0001 after adjustment for gender, age, BMI, and family history of diabetes). This evidence concerns the gene INS and diabetes mellitus.