INS and Impaired glucose tolerance: After stratification of the cohort in normal glucose-tolerant subjects (N = 1139) and subjects with impaired fasting glycemia and/or impaired glucose tolerance (N = 439), all SNPs reported above to be significantly associated with fasting plasma glucose concentrations and measures of insulin secretion retained at least nominal associations with these traits in both subgroups (Supplementary Tables S1, S2, S3 and S4).