It has been proposed that constitutive STAT3 activation can result from aberrant EGFR signalling (Chan et al, 2004) and a significant correlation between high overall levels of P-STAT3 expression and overexpression of EGFR and HER-2/neu has been reported in ovarian cancer specimens (Rosen et al, 2006). The gene discussed is ERBB2; the disease is ovarian cancer.