UBTF and adenoviridae infectious disease: However, we did not observe significant changes in phosphorylation of UBF until 24 h p.i., whereas significant uncoupling of UBF from pol I does occur by 7 h p.i. This change in phosphorylation was not observed during adenovirus infection which supports the notion that UBF can be uncoupled from pol I without affecting its phosphorylation status, a hypothesis supported by recent reports that acetylation of UBF may also play a role (Meraner et al., 2006).