BMP7 and Alzheimer disease: These results support that both AD and SCC subtypes have suppressed TGF-beta signaling but through different mechanisms: in SCC there is increased expression of BMP7 that antagonizes TGF-beta functions [39], and reduced expression of TGFBR2, which suggests that SCC might be more sensitive than AD to targeting BMP7 or increasing expression of TGFBR2.