With this in mind, we considered of high interest previous reports showing that HRASG12V-induced IL8 expression plays a critical role in tumor growth and angiogenesis [35], that the degree of its expression was associated with the CRC induction and progression including the development of liver metastases [36,37], and that IL8 was a central element in CRC-specific gene network [38]. This evidence concerns the gene CXCL8 and colorectal carcinoma.