The levels of phospho-4E-BP1, eIF4E, and phospho-S6-ribosomal protein immunoreactivity were also upregulated in the PIN lesions (Figure 3A(viii,x,xii)), indicating that the AKT/mTOR/S6K axis was activated in the prostatic lesions. Here, AKT1 is linked to prostate intraepithelial neoplasia.