Because all available vCJD samples from the UK were included in the discovery phase, we went on to compare the top-ranked SNP associations and additional SNPs at the PRNP locus with a large and diverse collection of patients with prion disease, including those with iatrogenic CJD (iCJD), sporadic CJD (sCJD), and kuru. Here, PRNP is linked to variant Creutzfeldt-Jakob disease.