PRNP and prion disease: The risk conferred by rs6116492T could act through altered expression of PRNP owing to the crucial role for PrP in prion disease pathobiology; however, we have no direct evidence that a putative genetic risk conferred by rs1460163 or rs6794719 is manifest through their nearest genes (STMN2 or RARB) because these SNPs have no linkage disequilibrium with coding regions.