In a retrospective clinical study of more than 60 colorectal carcinomas, aberrant p53 expression was related with high expression of TSP1 and lymph node metastases.(66) Patients with primary colorectal cancer with low TSP1 expression, with or without detection of mp53 gene product, were more likely to have lymph node metastasis than patients with higher expression. This evidence concerns the gene THBS1 and colorectal carcinoma.