Notably, obatoclax disrupted the protection afforded by Bcl-2, Mcl-1, Bcl-xl, and Bcl-w in a Bax and Bak reconstituted yeast system, and inhibited colony formation of Eμ–myc lymphoma cell lines overexpressing Bcl-2, Mcl-1, and A1, suggesting that it can target multiple pro-survival Bcl-2 family members 24. This evidence concerns the gene MCL1 and lymphoma.