While a number of common genetic events have been implicated in human prostate carcinogenesis including those targeting PTEN, RB, and p27 tumor suppressors, NKX3.1 tumor modulator, and the c-Myc oncogene[1], [2], [3], [4], [5], the genetic and biological basis governing progression to invasive and metastatic or AI disease is less well understood. The gene discussed is NKX3-1; the disease is neoplasm.