In contrast, mice deficient in either CCR1, CCR2 or CCR5 exhibited more prominent airway epithelial cell apoptosis, a severe denuding bronchiolitis with an accumulation of cohesive apoptotic debris within the airway, and perivenular/periarterial cuffing but there was a distinct lack of cuffing around the affected airways. Here, CCR2 is linked to bronchiolitis.