PRF1 and infection: However, immune splenocytes from perforin-/- mice were less effective at clearing MNV infection from the duodenum/jejunum (p = 0.0003, Figure 7C) or distal ileum (p = 0.0075, Figure 7B) than cells from either WT or IFNγ-/- mice, but more effective compared to transfer of non-immune cells in duodenum/jejunum (p = 0.0086) or distal ileum (p = 0.0001).