Upregulation of GADD45A is associated with increased apoptosis and cell cycle arrest p53 independently in a variety of soft tissue sarcomas [37].It inhibits transcription factors associated with tumor growth including the c-Jun N-terminal kinase (JNK) cascade and NFKB [38,39,41,55].For rhabdomyosarcoma, increased GADD45A expression was associated with less aggressive tumor behaviour [40].GADD45 may antagonize TNF-receptor mediated cytotoxicity [41]. The gene discussed is MAPK8; the disease is soft tissue sarcoma.