BIRC3 is associated with chemotherapy resistance in Ewing sarcoma, rhabdomyosarcoma [64] and prostatic cancer [65] and suppresses TNFalpha mediated cell death by preventing formation of TNF Receptor 1. It regulates pro-survival NFKB-signalling by promoting degradation of MAP3K14 [66]. This evidence concerns the gene NFKB1 and Ewing sarcoma.