NFKB is activated TRADD-, TRAF3- and FADD-dependently [38] and also plays a key role in the survival of tumor cells by inducing expression of anti-apoptotic genes such as Bcl2, Bcl2l1, vascular endothelial growth factor (VEGF), and X-linked inhibitor of apoptosis (XIAP). The gene discussed is TRADD; the disease is neoplasm.