High levels of Rho-GTP are detected in HT1080 cells. The inhibition of Rho by fasudil, a Rho kinase inhibitor lead to decreased tumor cell motility and growth in HT1080 cells [25] and associated to the development of metastases in several other malignant tumors [23,24].ARHGDIA is downregulated by doxorubicin in HT1080 cells [56]. The gene discussed is ARHGDIA; the disease is neoplasm.