NOS3 and diabetes mellitus: In order to test the hypothesis that the genotype effect is manifested in the subgroup of patients with T2DM, we analysed the effect of the eNOS Asp298 allele using the subjects with Glu298/Glu298 as reference group, stratifying for diabetes, and adjusting for age, BMI, systolic blood pressure, serum triglycerides, HDL -cholesterol, current smoking, and leisure time physical activity.