NOS3 and type 2 diabetes mellitus: T2DM (HR 4.04 [2.61–6.27], p < 0.001) was an independent risk factor for AMI in a multivariate model (adjusted for age and sex), and remained significant when also entering the eNOS Asp298 dichotomized using a recessive model (Asp298/Asp298 versus Asp298/Glu298+ Glu298/Glu298).