Platelet‐derived growth factor (PDGF) and its receptor (PDGFR) are frequently upregulated in both low‐grade astrocytoma and oligodendroglioma along with a defined subset of GBM (∼13%), and the elevated expression of both suggests that autocrine/paracrine loops between ligand and receptor enhance their impact in glioma biology 10, 13, 53, 87. This evidence concerns the gene PDGFRB and glioma.