PRDM2 and Hepatic fibrosis: The pathways showing epigenetic alterations in various stages of liver fibrosis (up to cirrhosis) include: cell proliferation (p16, RIZ1/PRDM2, HIC-1, etc.), the Wnt/β-catenin pathway (APC, CDH1, SFRP1-4, etc.), the Ras pathway (SPROUTY and RASSF1A), the Jak–STAT pathway (SOCS1, SOCS3), the TGFα pathway (RUNX3) and metabolism of xenobiotics (GSTP1, etc.).