Members of a family in which a putative partial loss-of-function mutation in LRP6 was identified were predisposed to early cardiovascular-related death associated with dramatically elevated levels of plasma LDL and triglycerides, hypertension, diabetes, and osteoporosis.(15) In addition, several mutant mouse models with induced or spontaneous mutations in Lrp6 have been identified and characterized, with some of these mice reported to have alterations in bone development.(49–52). This evidence concerns the gene LRP6 and diabetes mellitus.