NGFR and central nervous system cancer: We found that expression of cleavage-resistant forms of p75NTR (p75FasS, p75FasTM, and p75CRD130), which prevented receptor proteolysis, blocked p75NTR-mediated glioma invasion (Figure 4A and 4B), providing evidence to support a role for γ-secretase–dependent release of p75NTR ICD in mediating glioma invasion.