Infection of INS-1E cells by the recombinant adenoviruses, Ad-hUCP2, Ad-hU2Patient1and Ad-hU2Patient2, enhanced the mitochondrial content of the corresponding proteins around 15 times compared with that of control cells infected with the highest concentration of adenovirus containing the GFP and the inverted UCP2 cDNA (Figure 4). Here, UCP2 is linked to infection.