Although IP-10 does not appear to be sensitive or specific enough to supersede IGRA as tools for TB diagnosis, or to distinguish between active TB and LTBI, a number of conclusions can be drawn from our study: the supernatants of the Quantiferon Gold-In-Tube assays are a useful and robust resource for investigation of further proposed biomarkers, and we are currently investigating other cytokines as potential biomarkers to distinguish between active TB and LTBI using this sample bank. The gene discussed is CXCL10; the disease is tuberculosis.