Our studies showed that TOP2A amplification was associated strongly with HER2 amplification in gastric carcinoma: among the ten HER2 amplification cases, two (20%) showed TOP2A amplification, whereas one TOP2A amplification case showed no HER2 amplification showing that TOP2A could be amplified independent of HER2 in gastric carcinoma. The gene discussed is TOP2A; the disease is gastric carcinoma.