Anti-PreS antibodies can block HBV [27] and DHBV infection [28]–[31], and many mutations within aa 1 to 75 of HBV PreS1 [32] and aa 2 to 115 [33] of DHBV PreS (D-PreS) abrogate infectivity, as does prevention of PreS myristoylation. The gene discussed is SLC26A5; the disease is infection.