Although the distribution of the polymorphisms of the HER-2 gene did not display statistically significant associations with all lung cancer and control subjects, the 3 polymorphisms (-3444 C>T, -1985 G>T and P1170A C>G) of HER-2 gene were found to be associated with the risk of lung cancer in female, non-smoker and non-drinker subgroups. This evidence concerns the gene ERBB2 and lung cancer.