Interestingly, despite the generally higher frequency of many of the long-range interactions in these cells (Figure 1C and 1D) and higher levels of expression of PcG components such as EZH2 in colon cancer cells (HCT116 and DKO) than in any of the EC cells (Figure S6), the levels of the above PcG components and the associated H3K27me3 marks were found to be lower at all fragments in HCT116 and DKO cells as compared to undifferentiated Tera-2 cells (Figure 3D) (also compare Figure 3B and 3C with Figure S7A). Here, EZH2 is linked to malignant colon neoplasm.