Concerning this possibility, the levels of PcG proteins and the associated histone mark, H3K27me3, are higher in EC cells as compared to colon cancer cells (Figure 3D) while the opposite is seen for DNA methylation and a factor that interprets this methylation for transcriptional repression, MBD2 (Figures 2C and 5B and Figure S8). Here, MBD2 is linked to colonic neoplasm.